BERLIN — The GLP-1 receptor agonist albiglutide (Tanzeum) — aloof from the bazaar in 2017 — was above for abbreviation cardiovascular contest in bodies with blazon 2 diabetes, advisers appear here.
In the Harmony Outcomes trial, adults with blazon 2 diabetes with accustomed cardiovascular ache accustomed a account bang of albiglutide had a cogent abridgement in the primary blended aftereffect — stroke, myocardial infarction (MI), or cardiovascular (CV) afterlife — aback compared with placebo (HR 0.78, 95% CI 0.68-0.90, P<0.0001 for noninferiority, P=0.0006 for superiority).
Over the average 1.5-year aftereffect aeon of the trial, alone 7% (n=338) of the patients who were accustomed albiglutide in accession to their accepted affliction accomplished one of these above adverse cardiovascular contest compared with 9% (n=428) patients who did not accept the GLP-1 receptor agonist, appear Stefano Del Prato, MD, of the University of Pisa in Italy, and colleagues.
The allegation were presented at the anniversary affair of the European Association for the Abstraction of Diabetes (EASD) and accompanying appear in The Lancet.
This all-embracing abridgement in above adverse cardiovascular contest (MACE) was abundantly apprenticed by a abridgement in baleful or non-fatal MI risk:
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